Once Project MKUltra officially got underway in April, 1953, experiments included administering LSD to mental patients, prisoners, drug addicts and prostitutes, "people who could not fight back", as one agency officer put it. In one case LSD was administered to a mental patient in Kentucky for 174 days.
LSD was also administered to CIA employees, military personnel, doctors, other government agents, and members of the general public in order to study their reactions. LSD and other drugs were usually administered without the subject's knowledge or informed consent, a violation of the Nuremberg Code that the U.S. agreed to follow after World War II. The aim of this was to find drugs which would irresistibly bring out deep confessions or wipe a subject's mind clean and program him or her as "a robot agent". In Operation Midnight Climax, the CIA set up several brothels in San Francisco, California to obtain a selection of men who would be too embarrassed to talk about the events. The men were dosed with LSD, the brothels were equipped with one-way mirrors, and the sessions were filmed for later viewing and study. In other experiments where people were given LSD without their knowledge, they were interrogated under bright lights with doctors in the background taking notes.
The subjects were told that their "trips" would be extended indefinitely if they refused to reveal their secrets. The people being interrogated this way were CIA employees, U. S. military personnel, and agents suspected of working for the other side in the Cold War. Long-term debilitation and several deaths resulted from this. Heroin addicts were bribed into taking LSD with offers of more heroin.
The office of Security used LSD in interrogations but Dr. Sidney Gottlieb, the chemist who directed MKUltra, had other ideas: he thought it could be used in covert operations. Since its effects were temporary, he believed it could be given to high officials and in this way affect the course of important meetings, speeches etc. Since he realized there was a difference in testing the drug in a laboratory and using it in clandestine operations, he initiated a series of experiments where LSD was given to people in "normal" settings without warning. At first, everyone in Technical Services tried it; a typical experiment involved two people in a room where they observed each other for hours and took notes.
As the experimentation progressed, a point was reached where outsiders were drugged with no explanation whatsoever and surprise acid trips became something of an occupational hazard among CIA operatives. Adverse reactions often occurred, for example an operative who had received the drug in his morning coffee, became psychotic and ran across Washington, seeing a monster in every car that passed him. Incidents like that reaffirmed that LSD is a dangerous weapon but that only made them more enthusiastic. The experiments continued even after Dr. Frank Olson, an army scientist who had not taken LSD before, went into deep depression after a surprise trip and later fell from a thirteenth story window (it is unclear whether he committed suicide or was murdered before being thrown out of the window).
Some subjects' participation was consensual, and in these cases they appeared to be singled out for even more extreme experiments. In one case, seven volunteers in Kentucky were given LSD for 77 consecutive days.
LSD was eventually dismissed by MKUltra's researchers as too unpredictable in its results.
They had given up on the notion that LSD was "the secret that was going to unlock the universe," but it still had a place in the cloak-and-dagger arsenal. However, by 1962 the CIA and the army had developed a series of superhallucinogens such as the highly touted BZ, which was thought to hold greater promise as a mind control weapon. This resulted in the withdrawal of support by many academics and private researchers, and LSD research became less of a priority altogether.
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